Tweefractieschema's met lage en hoge bestralingssdosis ontlokken differentiële immuunresponsen

Radiotherapy exerts direct cytotoxic effects on cancer cells, but also induces immunogenic responses in the tumor microenvironment, eliciting both immune stimulatory and immune suppressive dynamics. These effects are influenced by fraction size, fractionation regimen and timing of radiotherapy-immunotherapy co-administration. In this study, two opposing two-fraction regimens were investigated, in which the same cumulative physical dose was applied to the tumor, but low and high dose fractions were administered in opposite order.