Neoadjuvante chemo-immunotherapie verbetert responspercentages bij hoofd-halskanker

Despite the recent approval of perioperative pembrolizumab for locally advanced, resectable head and neck squamous cell carcinoma, response rates to immunotherapy are low. A recent single-arm phase II trial of neoadjuvant nivolumab in combination with carboplatin and paclitaxel demonstrated improved pathologic response rates compared to either chemotherapy or immunotherapy alone.