Cognitieve uitkomsten na radiotherapie voor medulloblastoom: voxelgebaseerde analyse

For children diagnosed with medulloblastoma, treatment typically includes surgery, chemotherapy, craniospinal irradiation (CSI), and supplemental focal radiation (boost) to the primary site and, when indicated, metastatic sites1. Survivors face risks of impaired growth and development, endocrinopathy2,3, hearing loss4 , and cognitive deficits5, all of which can impact their social attainment6 and ability to achieve independence as adults7. A recent meta-analysis of childhood cancer survivors who received brain radiotherapy confirmed earlier findings that cognitive outcomes after treatment are correlated with the prescribed CSI dose and the volume of irradiated brain, even when adjusted for age and other factors8 .