Single-cell netwerk- en machine learning-analyse van ferroptose bij recidief glioblastoom

Recurrent glioblastoma multiforme (rGBM) arises after conventional treatment strategies for primary GBM (pGBM) fail, leading to a more aggressive, therapy-resistant phenotype, with an overall survival of ∼9 months. Current treatment strategies rely on apoptosis and are frequently ineffective. Moreover, ferroptosis has recently been identified as a potential alternative cell death pathway in glioma. Therefore, this study investigated the mechanisms and therapeutic potential of ferroptosis in rGBM at the glial cell type level.