Uterine Transposition Prior to Pelvic Radiation: First Canadian Center

Pelvic radiation therapy is central to the curative treatment of a range of malignancies, including rectal, anal, gynecologic, and pediatric pelvic tumors, but it inevitably leads to irreversible damage to reproductive organs.1 The ovaries are exquisitely radiosensitive, and doses as low as 2 Gy can impair ovarian reserve, whereas cumulative doses above 6 to 10 Gy usually result in permanent ovarian insufficiency.2 The uterus is also profoundly affected, because radiation therapy induces endometrial atrophy, myometrial fibrosis, and vascular compromise, resulting in amenorrhea, uterine shrinkage, and complete loss of reproductive capacity.