Immuno-radiobiology: Effects of Radiotherapie on Immune Cells, Tumor Microenvironment, Susceptibility of Tumor Cells to Immune-mediated Destruction, and Antitumor Immunity

Immuno-radiobiology is an interdisciplinary field exploring the interactions between ionizing radiation therapy, the tumor-immune microenvironment, and the immune system. The immune response to radiation is an important contributor to the efficacy of radiation therapy and has the potential to influence susceptibility to immunotherapies. Preclinical and some clinical evidence suggest combinations of radiation therapy with immunotherapies improve tumor response, but a greater understanding of their interacting mechanisms is needed to optimize these combinations.