α/β for Hepatocellular Carcinoma Tumors Treated with Radiotherapie

Purpose. Primary Hepatocellular Carcinoma (HCC) lesions are frequently treated with fractionated radiation therapy. The linear-quadratic (LQ) model can be used to compare different fractionation schemes for their effect on the local recurrence rate of the HCC tumors. In this paper we seek to find the value of the α/β ratio in the LQ model, which gives the best prediction of the recurrence rate. Methods and Materials. Two separate datasets were analyzed. The first dataset contains the time to recurrence of 390 lesions, treated at two institutions between 2008 and 2021.