Acute Toxicity and Cosmesis Following a Tumor Bed Boost After Whole Breast Moderate Dose Hypofractionation

Randomized evidence suggests that tumor bed boost improves local control following whole breast radiation therapy (WBRT) but may lead to more acute and late toxicity. However, little data are available about toxicity in real world practice from a tumor bed boost delivered after WBRT, particularly following moderate dose hypofractionation (MH). We evaluated acute toxicity and cosmesis effects associated with use of a boost after MH-WBRT in a large prospective cohort.