Fase 2-Prospectieve Trial of Personalized Radiotherapie Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer

We previously developed a model of pretreatment growth and on-treatment response dynamics, the proliferation saturation index (PSI) model, which derives the proliferating and radiosensitive proportion of a tumor based on clinically observed net growth before therapy. We hypothesized that personalization of fractionation using PSI would increase the percentage of patients achieving a rapid reduction in tumor size during radiation therapy (RT) for early-stage human papillomavirus related squamous cancers of the oropharynx.