Stereotactic Body Radiotherapie Augmented Checkpoint Inhibitor Immunotherapy Response in Heavily Pretreated Gemetastaseerd Osteosarcoma

Immunotherapy for relapsed/refractory (R/R) osteosarcoma has shown limited success because of its immunosuppressive microenvironment. Recent evidence suggests stereotactic body radiation therapy (SBRT) as not only a local therapy but also a modality with an immunomodulatory role. However, combining SBRT with immune checkpoint inhibitors (ICIs) is yet to be explored in osteosarcoma.