Genomisch landschap van NSCLC bij systemische sclerose: frequente TP53-mutaties

Systemic sclerosis (SSc) is a chronic connective tissue disease associated with a significantly elevated and disproportionate risk of developing NSCLC, yet the underlying molecular drivers remain poorly understood. Specifically, it is unclear how these tumors fit within the established molecular paradigms of lung cancer, particularly in relation to the patient's smoking status and its associated genomics. Here, we investigated the genomics of NSCLC in patients with SSc and other connective tissue diseases associated with interstitial lung disease (ILD).