Utility-Based Dose Selection for Stereotactic Body Radiotherapie in Hepatocellular Carcinoma

Stereotactic body radiation therapy (SBRT) planning for hepatocellular carcinoma (HCC) typically prescribes the maximum dose associated with an acceptable risk of toxicity, relying on implicit trade-offs between efficacy and toxicity. To make this trade-off quantitative, we developed a utility-based approach to dose selection for SBRT in HCC and studied the expected effects on clinical outcomes.